These are aggregated news stories from nephrology newsfeeds. All links lead to the original articles.
The first issue of NDT was published in 1986. In that issue, there were two reports by the ERA-EDTA Registry, five original articles, one technical report and one case report. It was a slow start, but with time, the first Editor of the journal, Professor Alexander (Sandy) Davison, fully succeeded in transforming...
Metabolic balance studies have a long and important history in medical research [1]. On the most fundamental level balance studies are used to quantitate whether the amount of a substance (mass) has been added, retained or lost from the body. Over a fixed period of time, input and output are measured, the latter is subtracted ...
Midkine (MK; gene name, Mdk), a heparin-binding growth factor, regulates cell growth, cell survival, migration and anti-apoptotic activity in nephrogenesis and development. In the kidney, MK is expressed mainly in proximal tubular epithelial cells and is induced by oxidative stress through the activation...
Haematuria is a frequent manifestation of glomerular disease. However, nephrologists devote more attention to the monitoring and therapeutic targeting of another key manifestation of glomerular injury, proteinuria. Recent reports have propelled haematuria to the forefront of clinical nephrology. Thus,...
Renal transplantation from living kidney donors is still relatively marginal in most of the European countries. However, this source of kidney grafts may help to overcome in part the organ donor shortage of cadaveric donors. The living donor strategy implies correct and objective information about donation...
In this pro-con debate, we will analyse the relevance of data supporting the prime role of uraemic toxins versus salt and volume overload as the main driver for the impressive mortality and morbidity characteristic of any end-stage renal disease patient.
Firstly, we are going to review the...
Dozens of inherited diseases affect the kidney; collectively, they account for at least 10% of patients with end-stage renal disease in Europe [1]. The underlying genetic defects may affect all structures and cell types of the nephron and may therefore compromise all aspects of kidney function. In...
On behalf of all our staff and the publisher OUP, we would like to convey our best wishes for the New Year to our readers, editors and reviewers and want to thank them all for their continuing support of the journal. With this editorial, we also provide an update on last year’s achievements.
Membranous nephropathy (MN) is the most common cause of the nephrotic syndrome in Europe, with an incidence of 5–10/million/year in adults [1]. Although MN can occur secondary to infections, systemic diseases, use of drugs or malignancies, in most patients no underlying cause is identified...
Pneumocystis jiroveci pneumonia (PJP) is a feared opprtunistic infection in the renal transplant population. The unicellular fungus is ubiquitous in the environment but has an untreated mortality of 90–100% in immunocompromised HIV-negative patients [1]. This falls to 35% with treatment [2]. Many, but not all, t...
Tubulo-interstitial fibrosis constitutes the final common pathway for all pathological conditions that evolve towards chronic kidney disease, and transforming growth factor-β1 plays a key role in this process. Furthermore, neutrophil gelatinase-associated lipocalin appears not only to be a simple marker of ...
Hepatorenal syndrome (HRS) is defined as the occurrence of renal dysfunction in a patient with end-stage liver cirrhosis in the absence of another identifiable cause of renal failure. The prognosis of HRS remains poor, with a median survival without liver transplantation of <6 months. However,...
Hepcidin is a 25-amino acid peptide with a defensin-like structure that is primarily synthesized in hepatocytes [1, 2]. It was independently isolated ∼10 years ago by two groups seeking peptides with antimicrobial activity in urine [3] and plasma [4]. Hepcidin was originally shown to have a weak selective antimicrobial activity against certain...
‘Elk voordeel hep zijn nadeel—every advantage has its disadvantage’ [Freely modified from Hendrik Johannes Cruijff, Dutch philosopher (and occasional soccer player), 1947- ]
If this author feels anything about pro–con debates, then it is that he is contra. Two people are forced into extreme black and white viewpoints, although in r...
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