Sir,
The article by Miyamoto et al.[1] recently published in this journal describes the role of organic anion transporters (OATs) in the uptake of p-cresyl sulfate (PCS) in rat renal cortical slices and a human proximal tubule cell model, viz. HK-2 cells. In this study, uptake of PCS in both model systems could be inhibited by several OAT inhibitors including probenecid and p-aminohippuric acid. As mentioned by the authors, specificity of PCS transport was investigated using well-known substrates for OATs at a concentration of 1 or 10 mM in renal slices or HK-2 cells, respectively. …
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