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Focal segmental glomerulosclerosis accounts for approximately 20% of cases of the nephrotic syndrome in children and 40% of such cases in adults, with an estimated incidence of 7 per 1 million.1 It is the most common primary glomerular disorder causing end-stage renal disease in the United States, with a prevalence of 4%.2 The cardinal feature is progressive glomerular scarring. Early in the disease course, glomerulosclerosis is both focal, involving a minority of glomeruli, and segmental, affecting a portion of the glomerular globe. With progression, more widespread and global glomerulosclerosis develops. Since the first clinical–pathological studies of the disease in the . . .
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From the Department of Pathology, Columbia University College of Physicians and Surgeons (V.D.D.); and the Division of Pediatric Nephrology, Albert Einstein College of Medicine (F.J.K.) — both in New York; and UNC Kidney Center and the Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill (R.J.F.).
Address reprint requests to Dr. D'Agati at Columbia University Medical Center, Division of Renal Pathology, Rm. VC14-224, 630 W. 168th St., New York, NY 10032, or at This e-mail address is being protected from spambots. You need JavaScript enabled to view it .
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