The Sheffield Kidney Institute has an established international reputation for excellence in the field of CKD research. This research has been led by Professor El Nahas over the last 25 years. It consists of parallel and translational approaches for the study of CKD from basic science focusing on mechanisms of kidney scarring and remodelling to clinical studies. Clinical CKD research at the Sheffield Kidney Institute focuses on studies of the epidemiology of CKD in the community. This has included the KEAPS (Kidney Evaluation and Awareness Programme for Sheffield) and the KEOPS (Kidney Evaluation of Overweight Population in Sheffield) research programs that delineated factors predisposing to CKD in the general population. CKD research in Sheffield was also the first in the UK to delineate a link between poverty and social deprivation with CKD. In addition to studies of the epidemiology and natural history of CKD, research is focusing on identifying biomarkers that would predict the severity and outcomes of patients with CKD. Finally, the Sheffield Kidney Institute is at the forefront of clinical trials on the impact of interventions on clinical outcomes in CKD.

Recent Publications:

  1. Socioeconomic status and chronic kidney disease at presentation to a renal service in the United Kingdom.
    Bello AK, Peters J, Rigby J, Rahman AA, El Nahas M.
    Clin J Am Soc Nephrol. 2008 Sep;3(5):1316-23.
  2. A population-based screening for microalbuminuria among relatives of CKD patients: the Kidney Evaluation and Awareness Program in Sheffield (KEAPS).
    Bello AK, Peters J, Wight J, de Zeeuw D, El Nahas M; European Kidney Institute.
    Am J Kidney Dis. 2008 Sep;52(3):434-43.
  3. Impact of Vitamin D Dose on Biochemical Parameters in Patients with Secondary Hyperparathyroidism Receiving Cinacalcet.
    Wilkie M, Pontoriero G, Macário F, Yaqoob M, Bouman K, Braun J, von Albertini B, Brink H, Maduell F, Graf H, Frazão JM, Bos WJ, Torregrosa V, Saha H, Reichel H, Zani VJ, Carter D, Messa P.
    Nephron Clin Pract. 2009 Apr 10;112(1):c41-c50.
  4. CKD and poverty: a growing global challenge
    Hossain MP, Goyder EC, Rigby JE, El Nahas M.
    Am J Kidney Dis. 2009 Jan;53(1):166-74.