The Kidney Genetics Group is led by Professor Albert Ong who has a major clinical interest in inherited kidney diseases. Our major research efforts are in studying autosomal dominant polycystic kidney disease (ADPKD) by taking a holistic approach from gene to patient. In particular, we aim to discover new treatments for ADPKD, to improve the clinical management of ADPKD patients and to understand better how cysts form and grow in the ADPKD kidney.
ADPKD is one of the most common monogenic human diseases known and affects around 1 in 500 people. It is caused by mutations in two genes, PKD1 and PKD2. ADPKD accounts for ~10% of patients with kidney failure in most renal units and could affect 5-10 million people worldwide. Although the two ADPKD genes have been identified, we still do not have a clear understanding of how and why cysts form in this disease and there are still no effective treatments for patients. Our work is currently supported by the Wellcome Trust, the Medical Research Council, Research Councils (UK), Kidney Research UK, the Polycystic Kidney Disease Foundation (USA), the Sheffield Kidney Research Foundation (SKRF), the Sheffield Area Kidney Patients Association (SAKA) and the Polycystic Kidney Disease Charity (UK).
Further information on our work can be found at http://www.shef.ac.uk/medicine/staff/ong.html
or by contacting Professor Ong at This e-mail address is being protected from spambots. You need JavaScript enabled to view it
CKD-Micro1
CKD Algorithm
CKD Tables